Immunologic differences in human isoferritins: implications for immunologic quantitation of serum ferritin

Immunologic differences in human isoferritins: implications for immunologic quantitation of serum ferritin.

Immunologic differences in several tissue isoferritin populations have been investigated using antibodies developed in rabbits against human liver ferritin and in guinea pigs against HeLa cell ferritin. Our results indicate that the quantity of ferritin measured by radioimmunoassays is markedly affected by the isoferritin and subunit composition of the ferritin sample as well as by the nature o...

Immunologic Studies with Ethylene Oxide-treated Human Serum

The antigenicity of an ethylene oxide-treated human serum in humans has been studied. The immune response to the material had many of the characteristics of a delayed cellular skin reaction. Even after repeated immunizations by intradermal skin testing over a period of 1(1/2) years, no detectable antibody could be found in the sera. The antigenicity has been shown to be associated with drastic ...

The immunologic identification and quantitation of human intrinsic factor in gastric secretions.

Dissecting the human immunologic memory for pathogens.

Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human ...

Lactoferrin and immunologic dissonance: clinical implications.

Homeostasis is the maintenance of equilibrium in a biological system by means of positive and negative feedback control mechanisms that counteract influences tending toward physiological dissonance. At the molecular level, homeostasis is controlled by the network of the neuro-endocrine-immune system, in which lactoferrin (LF) plays a central role. The purpose of this review is to provide a comp...